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Rescuers had earlier seen a hand protruding from the debris and the girl wiggled her fingers when asked if she was still alive.
At least 225 people have been killed following the 7.1 magnitude quake.
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They have fed a hose through the rubble to give her water.
Among the twisted concrete and steel ruin of the school, soldiers and firefighters found 22 dead children and two adults.
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Many are thought trapped in buildings that have collapsed or caught fire.
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Over two million people in the nation's south have been affected by the quake.
The southern town of Juchitan in Oaxaca state was hit particularly hard.
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It was the strongest earthquake to hit the country since 1985.
South Korea says North Korea may have conducted a sixth nuclear test, Yonhap reports citing the Blue House. The United States Geological Survey said a tremor that is 5.6 in magnitude struck North Kore...
Costas Baltas / Reuters
One person is dead and it's feared more could be trapped under the rubble.
Athens: A powerful earthquake has shaken the Greek resort island of Kos, killing two tourists, injuring more than 120 and damaging historic buildings and the main port . Greek authorities have confirm...
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The quake read 7.1 magnitude on the Ritcher Scale.
It could reveal how the planet formed.
Geoscience Australia has confirmed a 3.7 magnitude earthquake occurred east of Adelaide.