14/03/2017 10:44 AM AEDT | Updated 14/03/2017 3:05 PM AEDT

The Human Toll Of Syria's Bloody Conflict Numbers In The Hundreds Of Thousands

More than 460,000 people died or went missing.

Almost half a million people have died or gone missing since the war in Syria began six years ago, the British based Syrian Observatory for Human Rights (SOHR) says.

What began in 2011 as a "day of rage" protest against the rule of President Bashar al-Assad morphed into a struggle involving global and regional powers and left parts of the country in the grip of Islamic State.

The SOHR says about 465,000 people were killed or have gone missing in six years of revolutionary war, while 14 million have been wounded or displaced.

This Wednesday marks six years to the day since the bloody conflict began.

The war has created 4.9 million refugees and left 6.3 million people displaced internally, as well as millions more inside Syria living in daily fear of the war, UN High Commissioner for Refugees Filippo Grandi said.

"Unless drastic measures are taken to shore up peace and security, the situation will worsen," Grandi aid in a statement.

"Syria's trauma goes beyond its borders. The outflow of people and the seemingly unstoppable conflict have contributed to the climate of anxiety we see today in many countries. As I have said before, if you don't solve problems, the problems come to you."

The Syria conflict in numbers

  • 13.5 million need humanitarian aid;
  • 6.3 million are displaced internally;
  • Hundreds of thousands have made perilous sea voyages seeking sanctuary;
  • Nearly 3 million Syrians under 5 have grown up knowing nothing but conflict;
  • 4.9 million – the majority women and children – are refugees in neighbouring states, placing host communities under huge strain as they shoulder the social, economic and political fallout.
Source: UNHCR

A UN report issued last week found both sides of the conflict were responsible for war crimes during the battle for Aleppo last year during months of "unrelenting violence."

The SOHR said it had documented the deaths of more than 321,000 people since the start of the war and more than 145,000 others had been reported as missing.

The total number of civilian casualties is 96,073, 17,411 of them children, the SOHR said.

JOSEPH EID via Getty Images
A Syrian man drives his vehicle past destruction in the once rebel-held Aghiour neighbourhood in Aleppo during a sandstorm on March 10, 2017.
MOHAMMED EYAD via Getty Images
Smoke billows following reported air strikes by Syrian regime forces in the rebel-held area of Qabun, east of the capital Damascus, on March 6, 2017
Bassam Khabieh / Reuters
A man tries to put out a fire at a site hit by airstrikes in the rebel held besieged Douma neighbourhood of Damascus, Syria, February 26, 2017

Rebel shelling has killed more than 7,000 civilians, while casualties in detention centers and prisons of the regime saw 14,661 civilian casualties, the SOHR said.

Islamic State killed 3,723 civilians.

REUTERS/Khalil Ashawi
Women walk near damaged buildings in the northern Syrian city of al-Bab, Syria March 13, 2017.
Khalil Ashawi / Reuters
A rebel fighter looks for survivors under rubble of a damaged building after a car bomb explosion in Jub al Barazi east of the northern Syrian town of al-Bab, Syria January 15, 2017.
Getty Images
People leave the impact site after Assad Regime's airstrike over civilians in residential areas of Ariha town of Idlib, Syria on February 25, 2017. Many deaths and injuries reported.

The governments of Syria and Russia both deny targeting civilians or using torture or extrajudicial killings. Most rebel groups and Turkey also deny targeting civilians.

The US-led coalition says it tries hard to avoid civilian casualties and always investigates reports that it has done so.

AMER ALMOHIBANY via Getty Images
A fighter from Jaish al-Islam (Islam Army) fires a heavy machine gun in the rebel-held area of Harasta, on the northeastern outskirts of the capital Damascus, on February 21, 2017.
Rodi Said / Reuters
An internally displaced Syrian woman who fled Raqqa city carries a child in northern Raqqa province, Syria February 6, 2017.