Jimmy Kimmel broke down in his opening monologue as he responded to the events of the Las Vegas mass shooting where at least 59 people have died and over 520 were left wounded.
Kimmel was born in New York but moved to Vegas when he was just nine years old and was visibly shaken by the horrific attack as he attempted to make sense of it all to his audience.
"Here we are again," Kimmel began, "in the aftermath of another terrible, inexplicable, shocking and painful tragedy".
"It's the kind of thing that makes you want to throw up or give up. It's too much to even process, all these devastated families who have to live with this forever."
The late-night host tackled the gun reform debate criticising the common defense, "When an American buys a gun and kills other Americans, then there's nothing we can do about that -- Second Amendment, I guess. Our forefathers wanted us to have AK47s is the argument I assume".
Kimmel also focused on the politicians who offered their "thoughts and prayers" while also legislating in favour of easier access to weapons like President Trump, Paul Ryan and Mitch McConnell.
"Senate Majority Leader Mitch McConnell, Speaker of the House Paul Ryan and a number of other lawmakers who won't do anything about this because the NRA has their balls in a money clip also sent their thoughts and their prayers today which is good."
"They should be praying. They should be praying for God to forgive them for letting the gun Lobby run this country."
Displaying an image of the 53 senators who voted against closing the loopholes on background checks just days after the Orlando Pulse nightclub shooting.
"We have a major problem with gun violence in this country and I guess they don't care -- and if I'm wrong on that, fine do something about it because I'm sick of it."
"If feels like someone opened a window into hell. What I'm talking about tonight isn't about gun control, it's about common sense."