Chi Chi – real name Zavion Davenport – was best known for making it through to the final four in the eighth series of Drag Race, and later returned for the third All Stars run.
Last month, she was hospitalised with high blood pressure and suspected kidney failure, and was later discharged after undergoing dialysis treatment.
She returned to hospital earlier in August, where she told fans she had been diagnosed with pneumonia.
In the last few days, fans had been trying to raise money to help pay for Chi Chi’s treatment.
Chi Chi’s death was confirmed by Entertainment Weekly on Thursday evening.
A statement from World Of Wonder, the production company that makes Drag Race, said: “We’re heartbroken to learn that Chi Chi DeVayne has passed away today. Her drag spread a message of love and kindness that truly touched each person she met.
“Rest in power, Chi Chi.”
RuPaul said in a post on the show’s official page: “I am heartbroken to learn of the passing of Chi Chi DeVayne.
“I am so grateful that we got to experience her kind and beautiful soul. She will be dearly missed, but never forgotten. May her generous and loving spirit shine down on us all.”
A number of Chi Chi’s fellow queens, including those who appeared on Drag Race alongside her, have also been paying their respects on social media.
Kennedy Davenport – who competed with Chi Chi on All Stars 3 – wrote: “So i guess its true... I am num. I dont know what to even do or say.. my baby Zavion Michael Davenport.
“You fought so hard i am proud of you. REST IN THE LORD HE GOT YOU NOW. Keep dancing with the stars my angel. Im not ok [sic]”
Fellow All Stars 3 contestant Bebe Zahara Benet wrote: “My heart is breaking. You were such a light, a rare talent, a kind and generous spirit and a force of nature on the stage. Rest well, sister.”
Others who knew and worked with Chi Chi, including Bob The Drag Queen, Trinity K Bonet, Kim Chi and Trixie Mattel, have also been sharing their own tributes and memories of the much-loved performer.