The Duchess is said to have been concerned about how the former GMB host's comments would affect others struggling.
The celebrity chef and Jono Bennett recently called time on their 12-year marriage.
Viewers and media experts have called for a First Nations or culturally diverse woman to take on the role to reflect multicultural Australia.
The two-hour interview will air in Australia just hours after it hits screens in the US.
She said it's "incredibly important" to call out inappropriate behaviour, before speaking about her own experiences outside of work that "could’ve turned bad quickly”.
The Duchess of Sussex speaks out in the latest clip from Oprah Winfrey's upcoming interview with Prince Harry and Meghan.
Let the countdown begin.
The 25-year-old dazzled with her portrayal of the late Princess of Wales in the Netflix hit.
The TV judge took fans inside her shoe wardrobe, and we are obsessed.
There's more to the South Asian Australian home cook from Melbourne than meets the eye.